761例甲真菌病病原菌分离培养分析

Isolation and culture of causative pathogens for 761 cases of onychomycosis

目的了解医院近3年甲真菌病病原菌的种类和构成,观察其流行病学特点。方法对761例甲真菌病患者的病甲进行病原菌分离,将取材物进行KOH显微镜检查和真菌培养。结果临床分型:远端甲下型(DLSO)占65.18%,全甲营养不良型(TDO)占19.58%,近端甲下型(PSO)占9.99%,浅表白色型(SWO)占5.25%;共培养出致病真菌520株,皮肤癣菌占66.15%,以红色毛癣菌为主,占50.58%;酵母菌属占27.88%,以白色假丝酵母菌为主,占13.08%;烟曲霉菌占2.50%。结论临床分型以DLSO型为主,依次为TDO、PSO和SWO,甲真菌病病原菌以皮肤癣菌为主,其次为酵母菌属和真菌。

OBJECTIVE To get the message of fungal types and constitution on onychomycosis in latest 3 years.METHODS The causative fugi from nail samples of 761 patients with onychomycosis were isolated,material from the affected nail was obtained for KOH microscopic examination and culture.RESULTS DLSO（65.18%） was the most frequent clinical type,followed by TDO（19.58%）,PSO（9.99%） and SWO（5.25%）.Totally 520 strains of pathogenic fungi were cultured.The most frequently isolated fungus was dermatophytes（66.15%）,such as trichophyton rubrum（50.58%） and the yeasts（27.88%）,such as Candida albicans（13.08%）;Aspergillus fumigatus accounted for 2.50%.CONCLUSION DLSO is the major clinical type,followed by TDO,PSO and SWO.The most frequently pathogenic fungus of onychomycosis is dermatophytes,followed by yeasts and fungi.