摘要
目的:研究硬骨鱼紧张素ⅡT21M基因(UTS2-T21M)单核苷酸多态性(SNP)与东乡族原发性高血压(EH)的关系。方法:用PCR-RFLP及电泳分析法进行基因分型;SPSS软件分析各基因型与东乡族人群EH的相关性。结果:研究包括120例东乡族EH患者及102例正常人。EH患者与对照组间在基因型,等位基因频率上均有显著差异(P=0.021,0.014)。UTS2-T21M多态性,TT,TM,MM基因型的频率在病例组中分别40.0%,43.3%,16.7%;对照组相应基因型的频率为22.5%,55.0%,22.5%。T,M等位基因频率在病例组中分别61.7%,38.3%,对照组相应的等位基因频率为50.0%,50.0%。结论:UTS2-T21M基因多态性与东乡族人群EH相关。
Objective:To study the association of UTS2-T21M SNP with essential hypertension in Dongxiang nationality.Method:Genotyping of UTS2-T21M was conducted with PCR-RFLP and agarose gel electrophoreticanalysis.All statistical analyses were performed with SPSS.Result:120 essential hypertension(EH) cases and 102 healthy controls were studied.We found significant difference in genotypic and allelic frequency of T21M SNP in UTS 2 between EH patients and controls.(P=0.021,and 0.014,respectively).Frequencies of TT,TM,MM Genotypes were 40.0%,43.3%,16.7% in case,And were 22.5%,55.0%,22.5% in controls;Frequencies of T,M allele were 61.7%,38.3% in case and 50.0%,50.0% in controls.Conclusion:Genetic variants of T21M of UTS2 were association with essential hypertension in Dongxiang population.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2011年第1期41-43,共3页
Journal of Clinical Cardiology
基金
甘肃省自然科学基金(No:1010RJZA158)