Megsin C2093T、C2180T基因多态性与IgA肾病相关性的Meta分析

Relationship of polymorphism of megsin C2093T and C2180T with IgA nephrology:a Meta-analysis

目的评价megsin C2093T和C2180T基因多态性与IgA肾病的关系。方法计算机检索Medline、Embase、Cochranelibrary等数据库1980年1月-2010年8月发表的文献,手工检索2000年1月-2010年8月的肾脏病相关杂志以及参考文献,纳入关于megsin C2093T和(或)C2180T基因多态性与IgA肾病易感性或IgA肾病进展关系的研究,采用RevMan 5.0软件进行分析。结果最终纳入5篇文献,Meta分析结果显示,2093C等位基因与IgA肾病易感性存在统计学差异(OR=1.20,95%CI 1.04～1.40),而2093CC基因型与IgA肾病的易感性无统计学差异(OR=1.18,95%CI 0.90～1.55);以亚洲人群为对象的2093C等位基因与IgA肾病易感性存在统计学差异(OR=1.19,95%CI 1.01～1.40),2093 CC基因型与IgA肾病易感性无统计学差异(OR=1.19,95%CI0.88～1.61)。Megsin 2180C等位基因及CC基因型与IgA肾病易感性均无统计学差异(C基因OR=0.89,95%CI 0.72～1.10;CC基因型OR=1.04,95%CI 0.69～1.56)。Megsin 2093和2180位点的C等位基因与IgA肾病进展均无统计学差异(2093位点OR=0.89,95%CI 0.69～1.15;2180位点OR=0.84,95%CI 0.48～1.46),CC基因型与IgA肾病进展同样无统计学差异(2093位点OR=0.80,95%CI 0.42～1.49;2180位点OR=0.79,95%CI 0.32～1.93)。2093T-2180T单体型与IgA肾病进展存在统计学差异(OR=0.54,95%CI 0.33～0.87)。结论 Megsin 2093C等位基因是IgA肾病的易感基因,而megsin 2093基因型2、180等位基因及基因型与IgA肾病的易感性无关。2093T-2180T单体型在IgA肾病的进展中有保护作用。

Objective To analyze the relation between the polymorphism of megsin C2093T and C2180T gene and IgA nephropathy.Methods Studies related to the relation of polymorphism of megsin C2093T and C2180T to IgA nephropathy were authenticated from databases including Medline,Embase and Cochrane Library from Jan.1980 to Aug.2010.The cited literature of obtained articles and some core English and Chinese medical journals relevant to nephropathy were also searched by hand（2000 to Aug.2010）.The data were analyzed by RevMan 5.0 software.Results Five papers were finally included,meta-analysis results showed that there was statistical difference between megsin 2093C allele and risk for IgA nephropathy [odds ratio（OR） = 1.20,95% CI 1.04 to 1.40].No statistical difference existed between megsin 2093CC genotype and risk for IgA nephropathy（OR=1.18,95% CI 0.90 to 1.55）.In Asian subgroups,there was significant difference between megsin 2093C allele and risk for IgA nephropathy（OR=1.19,95% CI 1.01 to 1.40）,while no significant association existed between megsin 2093CC genotype and risk for IgA nephropathy（OR=1.19,95% CI 0.88 to 1.61）.Also,no significant difference was revealed in the total meta-analysis between the megsin 2180C allele and risk for IgA nephropathy（OR=0.89,95%CI 0.72 to 1.10） or CC genotype and risk for IgA nephropathy（OR=1.04,95%CI 0.69 to 1.56）.Moreover,no significant difference was found between megsin 2093 and 2180C allele and IgA nephropathy progression（OR=0.89,95%CI 0.69 to 1.15;OR=0.84,95%CI 0.48 to 1.46,respectively）.There was also no significant difference between megsin 2093 and 2180CC genotype and IgA nephropathy progression（OR=0.80,95%CI 0.42 to 1.49;OR=0.79,95%CI 0.32 to 1.93,respectively）.Significant difference was found between the 2093T-2180T haplotype and IgA nephropathy progression（OR=0.54,95%CI 0.33 to 0.87）.Conclusion Megsin 2093C allele is the susceptible gene of IgA nephropathy,while megsin 2093 genotype,2180 allele or genotype are not.The 2093T-2180T haplotype plays a protective effect on the progression of IgA nephropathy.