BMSCs在急性肺损伤中的研究进展

RESEARCH PROGRESS OF BONE MARROW MESENCHYMAL STEM CELLS IN ACUTE LUNG INJURY

目的对BMSCs在急性肺损伤(acute lung injury,ALI)中的基础研究、临床进展及其机制进行综述。方法查阅近年有关BMSCs在ALI中的基础研究及临床相关文献并进行综述。结果 BMSCs能主动归巢至肺损伤部位并通过分化参与组织修复,同时BMSCs能调节和平衡ALI时局部和全身炎性反应和免疫紊乱。目前BMSCs对ALI抗炎-免疫调节以及组织修复的机制尚不清楚。结论具有主动归巢、分化以及抗炎-免疫调节效应的BMSCs对ALI具有全面的生物学效应,有望应用于临床,也为ALI的基因-干细胞治疗奠定了基础。

Objective To review the basic research,the clinical progress,and the mechanism of bone marrow mesenchymal stem cells（BMSCs） in acute lung injury（ALI）.Methods The literature concerning the basic and clinical researches of BMSCs in ALI was reviewed.Results BMSCs can take the initiative to ＂homing＂ the site of lung injury and take participate in repair by means of differentiation,meanwhile BMSCs could regulate and balance local and systematic inflammatory response and immune disorders in ALI.Currently,the mechanism of BMSCs on anti-inflammation and immune regulation in ALI is not clear.Conclusion BMSCs have comprehensive biological effect on ALI,providing a potential clinical treatment and also laying the foundation for gene therapy and stem cell therapy of ALI in the future.