影响骨肉瘤生存率的多因素回归分析

Cox multivariate regression analysis of survival rate for osteosarcoma

[目的]探讨影响骨肉瘤术后生存的预后因素。[方法]对40例骨肉瘤患者平均随访56个月,计算5年总生存率及无瘤生存率,选择临床因素及分子生物学指标,采用比例风险模型进行多因素回归分析。[结果]本组5年总生存率为53.78%、无瘤生存率为45.00%;Cox多因素回归分析显示:肿瘤体积、肿瘤细胞坏死率(TCNR)、P-gp的表达是影响骨肉瘤术后预后的独立因素。[结论]肿瘤体积、P-gp的表达与骨肉瘤的预后呈负相关,TCNR与预后呈正相关。肿瘤体积、TCNR、P-gp的表达可作为判断预后的独立指标。

[Objective]To determine the independent prognostic factors of survival rate for osteosarcoma. [Methods]The clinical data of 40 patients with osteosarcoma treated in our hospital from 1999 to 2005 were retrospectively analyzed,survival rate was calculated and 7 possible factors influencing survival rate were selected.A multivariate analysis was performed in these patients by the computer＇s Cox proportional hazard model.[Results]The overall survival rate was 53.78% and the event-free survival rate was 45.00% at five years.The multivariate analysis revealed that the mass of tumor,tumor cell necrosis rate（TCNR） and the expression of P-gp were independent prognostic factors for osteosarcoma.[Conclusion]The mass of tumor,TCNR and the expression of P-gp are the most important prognostic factors for osteosarcoma.