子宫内膜腺癌DNA结合抑制因子-1的表达及与雌激素受体(ER)α的相关性

Expression of inhibitors of DNA binding-1 in the endometrial adenocarcinoma and its correlation with ERα

目的探讨DNA结合抑制因子-1(Id-1)在子宫内膜腺癌组织中的表达状态及与雌激素受体(ER)α之间的关系。方法免疫组化法检测56例子宫内膜腺癌、18例子宫内膜不典型增生、20例正常子宫内膜组织中Id-1及ERα蛋白表达。结果在正常子宫内膜组织、子宫内膜不典型增生及子宫内膜癌中Id-1表达逐渐增强(P<0.05),ERα表达则逐渐减少(P<0.05)。Id-1蛋白阳性表达与组织分化程度及浸润肌层深度、手术病理分期有关(P<0.05)。ERα阳性表达与浸润肌层深度有关(P<0.05)。Id-1高表达患者的5年生存率低,但两组生存率差别无显著性意义(P>0.05)。Id-1与ERα表达之间呈正相关(r=0.284,P=0.034)。结论 Id-1在子宫内膜癌中存在着过表达,并且可能与ERα协同参与了子宫内膜腺癌的发生发展。

Objective To study the expression of inhibitors of DNA binding-1（Id-1） in endometrial adenocarcinoma and its correlation with ERα.Methods Id-1 and ERα proteins were analyzed using immunohistochemistry in 56 patients with endometrial adenocarcinoma,20 patients with normal endometria and 18 patients with atypia hyperplasia.Results The level of Id-1 expression was found in an increased order,while ERα was decreased from normal endometria to atypia hyperplasia,and then to endometrial adenocarcinoma（all P0.05）.The expression of Id-1 was significantly correlated with the histological grade,clinica1 stage and depth of myometrial invasion（P0.05）.ERα expression was significantly correlated with the depth of myometrial invasion（P0.05）.There was no association between the expression of Id-1 and survival time（P0.05）.Id-1 expression was positively correlated with ERα in endometrial adenocarcinomas（r=0.284,P=0.034）.Conclusions The expression of Id-1 is up-regulated in endometrial adenocarcinoma,and Id-1 coexpression with ERαmay take part in the progression of endometrial adenocarcinoma.