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喉鳞癌组织中Claudin-3和E-cad表达的临床意义 被引量：1

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摘要 目的检测Claudin-3及上皮型黏附素(E-cad)在喉鳞癌中的表达,探讨二者在喉鳞癌发生发展及转移中的作用。方法应用免疫组织化学法检测98例喉鳞癌组织及30例正常喉黏膜组织中Claudin-3、E-cad蛋白的表达情况,并将检测结果与临床病理特征进行综合分析。结果 Claudin-3蛋白阳性表达主要定位于喉鳞癌癌旁正常黏膜细胞质和细胞膜,E-cad蛋白阳性表达主要定位于喉鳞癌癌旁正常黏膜细胞膜,Claudin-3、E-cad蛋白在喉鳞癌中表达的阳性率明显低于正常黏膜。喉鳞癌中Claudin-3和E-cad蛋白的表达与肿物大小、分化程度、有无甲状软骨累及和淋巴结转移密切相关。结论 Claudin-3和E-cad在喉鳞癌组织中表达下调,二者可能与喉鳞癌的发生发展有关,联合检测Claudin-3和E-cad可能与喉鳞癌的预后密切相关。
作者 韩凤艳 刘爱东
机构地区 唐山市协和医院病理科 唐山职业技术学院病理教研室
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第2期202-203,共2页 Chinese Journal of Gerontology
关键词 喉鳞癌 CLAUDIN-3 E-CADHERIN 免疫组织化学
分类号 R739.65 [医药卫生—肿瘤]
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参考文献7

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二级参考文献23

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共引文献2

同被引文献28

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中国老年学杂志
2011年 第2期

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