摘要
随着葡萄糖浓度的增加,人肾小球系膜细胞转化生长因子β1(TGF-β1)、纤连蛋白(FN)和Ⅳ型胶原(ColⅣ)的表达显著增加(P<0.01).在30 mmol/L的高糖条件下,40~160 nmol/L的色素上皮衍生因子(PEDF)显著抑制TGF-β1表达,呈剂量依赖性(P<0.01);5~40 nmol/L的PEDF也剂量依赖性地抑制FN和ColⅣ的表达(P<0.01),提示PEDF可能通过其抗纤维化的作用延缓糖尿病肾病的进程.
The expressions of transforming growth factor β1 (TGF-β1), fibronectin (FN), and collagen Ⅳ in human mesangial cells were augmented with increased concentrations of glucose.Pigment epithelium-derived factor (PEDF) at concentrations of 40-160 nmol/L significantly inhibited TGF-β1 expression in a dose-dependent manner(P〈0.01).PEDF at concentrations of 5-40 nmol/L significantly decreased FN and collagen Ⅳ expressions in a dose-dependent manner(P〈0.01) ,suggesting that PEDF may play a salutary role in diabetic nephropathy by its antifibrogenic activity.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2011年第1期70-71,共2页
Chinese Journal of Endocrinology and Metabolism