硬组织植入材料表/界面研究进展

Progress in Research on the Surface/Interface of Materials for Hard Tissue Implant

硬组织植入材料表面和界面研究对改善和提高植入体性能及使用效果具有重要意义.本文从硬组织植入体的发展规律着手,综述了硬组织植入材料表面和界面研究的发展和趋势,并着重探讨了目前临床应用最为广泛的硬组织材料体系-钛及其合金的表面改性技术和研究动态.通过对钛及其合金进行表面改性,提高其骨再生能力和抗菌性是近年来的研究热点.表面负载生长因子和加涂生物活性涂层是提高钛合金植入体骨再生能力的常见手段,装载抗菌药物和负载抗菌元素是改善钛合金植入体抗菌性能的有效方法.随着纳米和生物技术的发展以及表面改性技术的革新,通过复合表面改性获得兼具生物活性和抗菌性的钛合金植入体是硬组织植入体的重要发展方向.

The investigation of the surface/interface of hard tissue implant materials is very important for improving their properties and application.This paper reviews the research progress and tendency of studies on the surface /interface for hard tissue implant,especially on titanium and titanium alloys,based on the law of hard tissue implant.The improvement of the bone regeneration and antibacterial properties of titanium-based alloys by surface modification has become the hot topics in recent years.Generally,loading growth factors and coating bioactive ceramics onto the surfaces of titanium and its alloys are valid ways to improve their ability of bone regeneration.And loading antibiotics and antibacterial agents have been proven to be an effective method to improve the antibacterial property of titanium implant.With the development of nanotechnology and biotechnology as well as the innovation of surface modification technologies,it is expected that to obtain titanium implants with combining bone regeneration and antibacterial properties by the hybrid surface modification.