阿拉伯树胶对胶原-羟基磷灰石复合材料性能的影响

Effects of Gum Arabic on Properties of Collagen-hydroxyapatite Composite

为改善胶原-羟基磷灰石复合材料的界面结合性能,将阿拉伯树胶引入该体系中,以Ca(NO_3)_2·4H_2O、(NH_4)_2HPO_4、酸溶胶原、阿拉伯树胶为原料,原位合成了胶原-羟基磷灰石/阿拉伯树胶复合材料.采用FT-IR,XRD,SEM表征材料的晶相结构、化学组成和微观形貌,研究了阿拉伯树胶对胶原-羟基磷灰石复合材料结构与性能的影响.结果表明,阿拉伯树胶改变了胶原-羟基磷灰石复合材料的界面形态与结构;随阿拉伯树胶含量的增加,胶原-羟基磷灰石复合材料的晶粒变小,结晶度降低;复合材料的吸水性能和体外酶降解能力都显著下降(P<0.01),其机械性能在一定范围内得到提高.阿拉伯树胶与胶原或胶原-羟基磷灰石之间可能形成了蛋白-多糖复合物,从而起到了交联作用.

In order to improve the interfacial bonding properties of collagen-hydroxyapatite（Col-HA） composite, gum Arabic was introduced in the system.Ca（NO3）2·4H2O,（NH4）2HPO4,acid dissolved collagen,and gum Arabic were used as the raw materials to in situ prepare collagen-hydroxyapatite/gum Arabic（Col-HA/Gum A） composite. Crystallite phase,chemical composition,and micro-morphology of the composite were characterized by XRD,FT-IR, and SEM.The effects of gum Arabic on the structure and properties of the collagen-hydroxyapatite composite were analyzed.The results indicate that both the interface structure and the surface morphology of the collagen -hydroxyapatite composite are changed by the introduction of gum Arabic.With increasing the amount of gum Arabic in the system,the sizes of the crystal grain and the crystallinity of the Col-HA composite are decreased.Both the hydrophilic properties and the enzymatic degradation capacity in vitro of the composite are decreased significantly （P0.01）,whilst the mechanical properties of the composite are improved in a certain range.Complexes of protein -polysaccharide can be formed between the gum Arabic and the collagen or collagen-hydroxyapatite,and the gum Arabic can act as a cross-linking agent in the new composite.