摘要
背景与目的生存率研究是反映癌症预后的一个重要指标。本研究旨在对启东2001年-2007年全人群肺癌登记病例进行生存率分析,为预后评价及防治提供依据。方法 4,451例登记病例的生存(死亡)情况随访截止于2009年12月31日;剔除只有死亡医学证明书(death certificate only,DCO)病例,实际纳入分析4,382例。用SURV 3.01软件计算观察生存率(observed survival,OS)及相对生存率(relative survival,RS),并应用Hakulinen氏似然比检验法进行统计学检验。结果肺癌1年、3年、5年OS分别为23.73%、11.89%和10.01%,1年、3年、5年RS分别为24.86%、13.69%和12.73%。其中男性1年、3年、5年RS分别为23.70%、12.58%和11.73%,女性1年、3年、5年RS分别为27.89%、16.53%和15.21%,女性生存率高于男性,两组之间的差异具有统计学意义(χ2=13.77,P=0.032)。15岁-34岁、35岁-44岁、45岁-54岁、55岁-64岁、65岁-74岁及75+岁各年龄组的5年RS分别为35.46%、17.66%、11.97%、13.49%、10.61%和15.14%。启东2001年-2007年5年RS比1972年-2000年有了很大的提高。结论启东市全人群肺癌登记病例总体生存率有了较大的提高,但与国外发达国家相比尚有一定的差距,应当继续重视肺癌的诊治研究。
Background and objective Lung cancer is one of the most important malignancies in China.Survival rates of lung cancer on the population-based cancer registry for the years 2001-2007 in Qidong were analysed in order to provide the basis for the prognosis assessment and the control of this cancer.Methods Total 4,451 registered lung cancer cases was followed up to December 31st,2009.Death certificates only(DCO) cases were excluded,leaving 4,382 cases for survival analysis.Cumulative observed survival rate(OS) and relative survival rate(RS) were calculated using Hakulinen's method performed by the SURV 3.01 software developed at the Finnish Cancer Registry.Results The 1-,3-,and 5-year OS rates were 23.73%,11.89%,10.01%,and the RS rates were 24.86%,13.69%,12.73%,respectively.The 1-,3-,and 5-year RS of males vs females were 23.70% vs 27.89%,12.58% vs 16.53%,and 11.73% vs 15.21%,respectively,with statisitically significant differences(χ2=13.77,P=0.032).RS of age groups of 15-34,35-44,45-54,55-64,65-74 and 75+ were 35.46%,17.66%,11.97%,13.49%,10.61%,15.14%,respectively.Remarkable improvement could be seen for the 5-year RS in this setting if compared with that for the years 1972-2000.Conclusion The lung cancer survival outcomes in Qidong have been improved gradually for the past decades.Further measures on the prevention,diagnosis and treatment of lung cancer should be taken.
出处
《中国肺癌杂志》
CAS
2011年第1期23-27,共5页
Chinese Journal of Lung Cancer
关键词
肺肿瘤
生存率
流行病学
Lung neoplasms
Survival
Epidemiology