干扰素诱导蛋白p204调节心肌分化的机制及应用前景

The Interferon-inducible p204 Protein Regulate Cardiac Differentiation:Mechanisms and Application Prospect

干扰素诱导蛋白p200家族蛋白包括6种鼠类及4种人类家族成员,具有共同的特征结构,广泛参与调节细胞增殖和分化、衰老和凋亡,在自身免疫反应、抗病毒及抗癌等领域发挥着重要的作用。内源性的p200家族蛋白鼠p204在心肌及骨骼肌表达最高,提示其在肌分化中起着重要作用。本文联系p204的分子结构及调节细胞生长与分化的功能,阐述p204促骨骼肌成肌细胞及胚胎癌细胞分化的机制,及对心肌损伤后心肌再生的应用前景。

The interferon-inducible protein 200 family characteristic structures and are highly homologous to one another, （p200） proteins, which have several common include 6 kinds of murine and 4 kinds of human family members, are widely involved in regulating cell proliferation and differentiation, senescence and apoptosis, playing important roles in the autoimmune response, anti-virus, anti-cancer and other fields. The endogenous murine p204 of p200 family proteins has the highest expression in heart and skeletal muscle, suggesting that it plays an important role in muscle differentiation. This article links the molecular structure of p204 and its functions of regulation of cell growth and differentiation, describes the mechanisms of p204 to promote skeletal myoblast, embryonal carcinoma cell differentiation and its application prospect for myocardial regeneration after cardiac injury.