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Wnt/β-catenin信号通路与干细胞衰老 被引量：3

Wnt/β-catenin Signaling and Stem Cell Aging
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摘要 Wnt/β-catenin信号通路作为一条进化保守的信号通路,有着广泛的生物学作用。研究发现,Wnt/β-catenin信号通路与干细胞衰老之间存在联系。激活Wnt/β-catenin信号通路可导致干细胞发生衰老变化,而抑制Wnt/β-catenin信号通路可延缓干细胞的衰老。本文对Wnt/β-catenin信号通路与干细胞衰老之间的关系及其作用机制作一综述。 The Wnt/β-catenin signaling is an evolutionarily conserved signaling pathway which has extensively biological function.Recent researches suggest that the Wnt/β-catenin signaling influences stem cell aging.The Wnt/β-catenin signaling may accelerate the aging of stem cell,and the age-related changes in stem cell may be delayed by altering the Wnt/β-catenin signaling directly.This review focused on the relationship between the Wnt/β-catenin signaling and stem cell aging and the mechanism of the Wnt/β-catenin signaling promoting stem cell aging.
作者 张大勇 谭玉珍 王海杰
机构地区 复旦大学上海医学院人体解剖与组织胚胎学系 浙江大学城市学院
出处 《中国细胞生物学学报》 CAS CSCD 2011年第1期72-77,共6页 Chinese Journal of Cell Biology
基金 国家自然科学基金(No.30470883 No.30971674) 高等学校博士点专项科研基金(No.200802460044)资助项目~~
关键词 干细胞 衰老 WNT/Β-CATENIN信号通路 stem cell aging Wnt/β-catenin signaling
分类号 R363 [医药卫生—病理学]
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参考文献42

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同被引文献59

  • 1张慧,陈华宁,库德莱迪·库尔班,王松娜,刘嘉扬,赵缜,叶丽.Wnt/β-catenin信号通路与癌症发生发展及其免疫治疗[J].中国生物工程杂志,2022,42(1):104-111. 被引量：8
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中国细胞生物学学报
2011年 第1期

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