SELDI-TOF-MS技术寻找肿瘤转移相关的标志蛋白研究进展

Research Progress for Searching Tumor Metastasis-related Protein Markers by SELDI-TOF-MS Technology

由于SELDI-TOF-MS技术简便、快速、灵敏度高、重复性好等优点,目前大量应用于肿瘤相关的研究,不但为肿瘤早期诊断相关标志蛋白的寻找提供了有效的手段,而且它在寻找肿瘤转移相关的标志蛋白中的作用越来越受到人们的关注。因为对于肿瘤转移相关标志蛋白的检测有利于人们更清楚地认识肿瘤转移的机制,更重要的是为临床医生提供对病人情况的更全面的判断,制定更适合病人自身的个体化的治疗方案。本文对国内外发表的利用SELDI-TOF-MS技术寻找在大肠癌、胃癌、肺癌、乳腺癌、前列腺癌、卵巢癌、肝细胞肝癌、头颈部癌等转移相关标志蛋白的研究文献作一综述。

Due to the advantages of SELDI-TOF-MS technology including simpleness,fastness,high sensitivity and good repeatability,this technology is widely applied in the tumor-related research and provides effective methods of searching tumor-associated protein markers,which,in particular,gets more and more attention because of the roles it played in searching for tumor metastasis-related protein markers.This paper presents and summaries in detail the relative research of the SELDI-TOF-MS technique in search of the tumor metastasis-associated protein markers.