静脉注射用人免疫球蛋白治疗20例重症药疹并发严重皮肤感染患者疗效分析

Intravenous immunoglobulin treatment of severe drug eruptions compticated with severe skin infections

目的:探讨重症药疹并发严重皮肤感染的合理治疗方法。方法:回顾性分析20例重症药疹并发严重皮肤感染患者的治疗情况。结果:20例患者经过糖皮质激素联合静脉注射用人免疫球蛋白、敏感抗生素抗感染、局部皮损处理、营养支持等治疗后均痊愈出院。结论:糖皮质激素联合静脉注射用人免疫球蛋白能有效治疗重症药疹,应尽早选用敏感抗生素控制皮肤感染,尤其是耐甲氧西林金黄色葡萄球菌感染的抗生素。局部皮损的处理及全身营养支持也极为重要。

Objectives： To investigate appropriate treatment of patients with severe drug eruptions complicated with serious skin infections. Methods： Clinical data of 20 patients with severe drug eruptions coexisting with skin infections were retrospectively analyzed. Restilts： All patients were cured with glucocorticoid combined with intravenous immunoglobulin （IVIg）, sensitive antibiotics, topical treatment and supportive therapy. Conclusions： Glucocorticoid combines with IVIg are effective and safe in the treatments of severe drug eruptions. Sensitive antibiotics should be used as soon as possible when serious skin infection coexists, especially with methieillin resistant staphylococcus aureus infection. Topical treatment and supportive therapy also play a pivotal role in the treatment of severe drug eruptions.