生长抑素治疗术后急性粘连性肠梗阻

Octreotide for the treatment of postoperative acute adhesive small bowel obstruction

目的 探讨生长抑素在治疗术后急性粘连性肠梗阻中的作用.方法 将87例术后急性粘连性肠梗阻患者分为治疗组（46例）及对照组（4l例）.对照组采用常规治疗,包括胃肠减压、灌肠、补液及抗感染治疗等;治疗组在常规治疗的基础上加用奥曲肽（生长抑素类似物）0.1 mg ihq8 h,治疗72 h,观察两组患者症状体征缓解情况及中转手术率的情况;结果治疗组较对照组腹痛改善及排气时间明显缩短,胃肠减压量减少较快.结论 在急性粘连性肠梗阻的常规治疗基础上加用生长抑素,可明显改善临床症状,促进肠道功能的恢复.

Objective To study the effect of octreotide on patients with postoperative acute adhesive small bowel obstruction. Method In this study, 87 patients with postoperative acute adhesive small bowel obstruction were divided into 2 groups： experimental group （46 patients） and control group （41 patients）. Patients in the control group were treated with routine therapy, including gastrointestinal decompression, intravenous infusion, antibiotic and enema. Patients in the experimental group were treated with routine therapy plus somatostatin analogue （octreotide） 0.1 mg. ih q8 h. for 72 hour. The alleviation of abdominal symptom and sign and the possibility of surgical intervention are observed and compared.Results Compared to the control group, the obstruction in the experimental group alleviated significantly,the abdominal pain relieved, the amount of draining decreased, and the passage of gas was earlier.Conclusions Based on the routine therapy, the use of octreotide significantly relieves the symptoms of obstruction and shortens the course of conservative therapy.