380例结直肠癌卵巢转移的相关因素分析

Analysis of Correlated Factors of Ovarian Metastasis in 380 Colorectal Cancer Cases

目的:探讨影响结直肠癌卵巢转移的临床病理相关因素。方法:收集2004年1月～2009年2月广西医科大学第一附属医院的结直肠癌女性患者380例的临床病理资料。选择经期关系、民族、病程、首发症状、肿瘤部位与大小、肿瘤与腹膜返折、浸润肠腔周径、大体类型、组织病理类型、分化程度、肠壁浸润深度、淋巴结转移、血总蛋白及白蛋白水平、血清CEA、大便潜血作为研究因素。采用非条件Logistic回归单因素分析,并对有统计学意义的变量进行非条件Logistic回归多因素分析。结果:380例结直肠癌女性患者发现54例(14.2%)出现同时性或异时性卵巢转移。单因素分析示:经期关系、病程、首发症状、肿瘤最大直径、浸润肠腔周径、组织病理类型、分化程度、肠壁浸润深度和血清CEA与结直肠癌卵巢转移有关。多因素分析示:经期关系、首发症状、浸润肠腔周径、病理类型、分化程度和血清CEA均为大肠癌卵巢转移的相关指标。结论:经期关系、首发症状、浸润肠腔周径、组织病理类型、分化程度和血清CEA是结直肠癌发生卵巢转移的临床病理相关因素。

Objective： To investigate the clinicopathologic factors related to ovarian metastasis in 380 colorectal cancer cases. Methods： Clinicopathologic data from a total of 380 patients with colorectal cancer treated in our hospital between January 2004 and February 2009 were collected. Parameters that were examined included mesomorphic phase, disease course, primary symptoms, tumor location, tumor size （cm）, peritoneal reflection, tumor circumference, tumor gross type, histological type, grade of tumor differentiation, depth of invasion, N status, total protein levels, ALB levels, FOBT, and serum CEA levels. Univariate and multivariate analyses were used to evaluate the relevant factors by Binary logistic regression （SPSS 13.0 for windows）. Results： Of the 380 cases, 54 （14.2%） cases had ovarian metastases. Mesomorphic phase, disease course, primary symptoms, tumor size （cm）, tumor circumference, histological type, grade of tumor differentiation, depth of invasion and serum CEA levels were found to be predictors that could affect ovarian metastasis in univariate analysis. Mesomorphic phase, primary symptoms, tumor circumference, histological type, grade of tumor differentiation, and serum CEA levels were independent risk factors related with colorectal ovarian metastasis in multivariate analysis. Conclusion： Mesomorphic phase, primary symptoms, tumor circumference, histological type, grade of tumor differentiation, and serum CEA level were the clinicopathologic factors related to ovarian metastasis from colorectal carcinoma.