散发型戊型肝炎与急性乙肝临床特征比较

Comparison of clinical features in acute hepatitis E and B

目的比较散发型急性戊型肝炎与乙肝临床特征。方法分析戊肝和急性乙肝间年龄、性别、肝脏损伤、症状体征以及病程的差异。结果急性肝炎病例中,戊型肝炎最常见(28.0%),急性乙肝次之(9.2%);戊肝平均发病年龄为56.3±13.1岁,急性乙肝为43.0±12.5岁,平均发病年龄戊肝较急性乙肝大(t=4.4723,P<0.0001),均为男性多发;两者常见的临床症状和体征基本相当,但戊肝患者黄疸症状更多见(P<0.05);戊肝病程较急性乙肝长(t=3.7249,P=0.0003);通过年龄性别进行1:1匹配分析,戊肝比急性乙肝对肝脏的损伤程度严重(t=3.5978,P=0.0019)。结论戊肝多见于中老年,急性乙肝多见于中青年,均为男性多于女性。临床特征比较戊肝较急性乙肝更为严重。

In order to compare the clinical features between sporadic hepatitis E and acute hepatitis B,the age,gender,liver injury,clinical symptom and disease course between acute hepatitis E and B detected in active surveillance were analyzed.ThE results showed that Hepatitis E（28.0%） was the most common disease in acute hepatitis,following by acute hepatitis B（9.2%）;the average age of onset of hepatitis E（56.3±13.1） was higher than that of acute hepatitis B（43.0 12.5）,and the difference was statistically significant（t=4.4723,P0.0001）.In the detected cases,male pateint were mone than that of female,there was no difference in clinical symptoms of both hepatitis E and B;except that jaundice in hepatitis E was more common than acute hepatitis B（P0.05）;illness course of hepatitis E was longer than that of acute hepatitis B（t=3.7249,P=0.0003）;by 1：1 match of age,liver injury in hepatitis E was severer than that in acute hepatitis B（t=3.5978,P=0.0019）.Tn conclusin male patinent were mort than that of female,Hepatitis E was common in middle aged people but in young people it was acute hepatitis B.Both hepatitis E and B were more common in men than women.Hepatitis E was severer than acute hepatitis B by comparing the clinical symptoms.