2009年甲型H1N1流感大流行期间上海市人群甲型H1N1流感疫苗接种前流感感染率调查

Investigation on infection rate of flu in healthy people in Shanghai during the 2009 H1N1 influenza pandemic before H1N1 vaccination

目的了解2009年甲型H1N1流感大流行期间,上海市健康人群甲型H1N1流感、甲型季节性流感H1和乙型季节性流感BY、BV抗体水平,以掌握流感流行或大流行的规律。方法采用分层抽样的方法随机选取不同职业重点人群作为研究对象,应用血凝抑制试验对其血清进行流感病毒抗体检测。结果 2009年下半年,共检测上海市531名不同职业人群的各型流感抗体水平,其中甲型H1N1流感和季节性流感H1、BY、BV抗体阳性率分别为53.7%、83.6%、71.6%、13.9%。不同人群各型流感抗体水平阳性率有所不同。甲型H1N1流感抗体水平以小学生最高,几何平均滴度(GMT)=77.9;其次是医务人员,GMT=69.3;最低为公安系统工作人员,GMT=10.1。结论在2009年甲型H1N1流感大流行期间,上海市健康人群甲型H1N1流感抗体阳性率较高,且不同年龄、不同职业人群之间抗体阳性率存在差异。甲型季节性流感抗体的阳性率高于乙型季节性流感抗体的阳性率。

Objective To investigate the level of antibody to influenza viruses of H1N1,seasonal influenza H1,BY and BV in healthy people in Shanghai and further to understand the epidemic trend of seasonal and pandemic influenza.Methods The hemagglutination inhibition（HI） test was conducted to detect the influenza antibody in serum from different occupational healthy people selected by stratified sampling in Shanghai,2009.Results In total,531 healthy Shanghai citizens were enrolled in the study.The total positive rates of H1N1,seasonal flu H1,BY and BV were 53.7%,83.6%,71.6% and 13.9%,respectively.And the antibody levels of different influenza types varied in different groups.For example,the H1N1 antibody level of the students was the highest,followed by the health workers and the workers in public security system.Conclusions During the 2009 H1N1 influenza pandemic,the H1N1 antibody positive rate was high in Shanghai population,varied among population with different age and occupation.The positive rate of seasonal influenza A was higher than that of seasonal influenza B.