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CD_4^+CD_(25)^+调节性T细胞和树突状细胞在HBV感染中的相互作用

Cross-talk between CD_4^+CD_(25)^+ Regulatory T Cells and Dendritic Cells in Patients with HBV Infection
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摘要 CD4+CD25+调节性T细胞(Treg)是迄今为止所发现的最重要的免疫抑制细胞,几乎抑制所有的免疫反应,在机体免疫系统中发挥负向调节作用。树突状细胞(DC)作为一类专职的抗原递呈细胞,在抗原识别、递呈中发挥重要作用,具有启动免疫应答和诱导免疫耐受的双重特性,对机体抗乙型肝炎病毒(HBV)起关键作用。作为在HBV致病机制中起重要作用的两个免疫细胞群——Treg与DC,探讨二者在慢性乙型肝炎发病机制中的相互作用,必将为进一步探索治疗HBV提供新的思路。 CD4^＋CD25^＋ regulatory cell （Treg）is one of an important immune supression cells among dicscoverable immune cells,which almost suppress all immune reaction and take negative regulatory function. Dendritic cell（DC） is one of full-time antigen presenting cell,which conducts its function in antigen recongnition and presantation, posses double characteristics in starting immune reaction and induing mimune tolerance, and also play key role in anti-hepatitis B virus （ HBV）. As two important ceils Treg and DC in the pathogensis of HBV infection, approaching the cross-talk between them might provide new method for treatment HBV.
作者 周培培 徐娟 颜学兵
机构地区 新泰市人民医院感染病科 徐州医学院附属医院感染病科
出处 《医学综述》 2011年第1期4-7,共4页 Medical Recapitulate
基金 江苏省卫生厅课题(H2008026) 江苏省高校自然科学基金(08KJB320017) 2008年江苏省高校"青蓝工程"中青年学术带头人培养基金
关键词 CD4+CD25+调节性T细胞 树突状细胞 乙型肝炎病毒 CD4^＋CD25^＋ T regulatory cells Dendritic cells Hepatitis B virus
分类号 R512.62 [医药卫生—内科学]
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参考文献28

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二级参考文献14

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医学综述
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