TLR-NF-κB信号通路与病毒性心肌炎的研究进展

Progress in the Study of TLR-NF-κB Signaling Pathway Associated with Myocarditis

Toll样受体是一类主要表达于炎性细胞与微生物识别有关的受体家族,在天然免疫反应中具有重要的作用。研究发现Toll样受体-核转录因子κB(TLR-NF-κB)信号转导通路的激活能够诱导炎性细胞释放炎性因子,介导炎性反应,同时介导先天性免疫向获得性免疫的转化,从而参与病毒性心肌炎(VMC)的病理、生理进程。因此,探讨VMC时TLR-NF-κB信号转导通路的作用,将为进一步揭示VMC的发病机制和寻求有效的防治措施提供重要的理论依据。

Toll-like receptor is a super family of receptors related with the recognition of microorganisms, and expressed on the surface of inflammatory cells, which plays a crucial role in natural immunity. Studies show that the activation of Toll-like receptor-nuclear factor kappa B（TLR-NF-κB）signaling transduction pathway can induce the activation of irnflammatory cells to secret pro-inflammatory cytokines to trigger the inflammatory responses,mediating the conversion from innate immunity to acquired immunity, involved in the pathophysiological process of viral myocarditis （VMC）. To investigate the effects of TLR-NF-κB signalingn pathway on VMC will provide a theoretical foundationfor revealing the pathogenesis of VMC and seeking effective preventive and therapeutic measures.