Treg/Th17分化失衡与炎症性肠病

Regulatory T Cells/Th17 Cells Differentiation Imbalance and Inflammatory Bowel Disease

炎症性肠病(IBD)的病因和发病机制尚未完全明确,其中免疫反应异常所导致的炎症过程在其发病中起重要的作用。新近研究发现,活化的CD4+T细胞亚群——调节性T细胞(Treg)和辅助性T细胞17(Th17)在分化发育和功能发挥的过程中受到多种细胞因子和转录因子的调节,共同维护机体的免疫平衡。有研究表明,Treg/Th17分化平衡是维护机体的免疫稳态的重要因素,其分化失衡在炎症性肠病的发生、发展中具有重要作用。

The etiology and pathogenesis of inflamatory bowel disease（IBD） remain incompletely understood. Inflammatory process caused by abnormal immune responses plays an important role in the pathogenesis of IBD. Recently, two new subsets of activated CD4^＋ T cells termed regulatory T ceils （ Treg cells） and Thl7 cells have been discovered,they are regulated by diverse cytokine and transcription factor in their development and function and they maintain immune balance in common. Some studies have shown that Treg/Th17 balance was critical in maintaining immune homeostasis. The differentiation imbalance of these two subsets may be involved in the pathogenesis of inflammatory bowel disease.