摘要
丹参酮ⅡA(TanⅡA)是唇形科鼠尾草属植物丹参的主要有效成分,具有抗炎、抗氧化作用,目前主要用于治疗心血管疾病。TanⅡA对多种肿瘤细胞有直接杀伤作用,并可诱导肿瘤细胞分化和凋亡,抑制肿瘤细胞的侵袭和转移,因此TanⅡA作为抗肿瘤药物具有较好的临床应用前景。其抗肿瘤作用机制与抑制DNA合成、抑制端粒酶活性、影响凋亡相关基因、干扰有丝分裂相关蛋白、改变肿瘤细胞表面蛋白的表达等因素有关。
Tanshinone Ⅱ A （Tan Ⅱ A）is the major component of Salvia mihiorrhiza bunge,which plays a role in the anti-inflammatory and anti-oxidant response. It is mainly applied to treat cardiovascular diseases at present. Recent studies show that Tan II A possesses cytotoxic activity against many human tumor cell lines, induces cell differentiation and apoptosis, and inhibits invasion and metastasis of cancer cells. As an anticancer drug ,Tan Ⅱ A has a promising future in clinical application. The anti-cancer mechanisms are related to the inhibition of DNA synthesis and telomerase activity, regulation of apoptosis genes ,interference with mitotic proteins ,and alteration in the expression of tumor cell surface proteins.
出处
《医学综述》
2011年第1期63-65,共3页
Medical Recapitulate
