非小细胞肺癌微转移检测及临床意义

Micrometastasis of Non-small Cell Lung Cancer and Clinical Significance

肺癌是常见的恶性肿瘤,非小细胞肺癌(NSCLC)占原发性肺癌的80%,相当一部分患者在原发肿瘤切除后出现肿瘤复发。即使是临床上通过影像学检查和手术的常规病理检查未发现有转移而诊断为早期的NSCLC患者,也有可能存在隐匿性转移,谓之微转移。微转移是行根治术后早期NSCLC患者死亡的主要原因。如何发现临床分期中尚属早期NSCLC患者的微转移,进而调整治疗策略和正确评估预后是近年来肺癌研究的热点。

Lung cancer is the most common malignancy in humans, and 80% of primary lung cancers are non-small cell lung cancer （NSCLC）. A fairly large number of patients relapse after operation. Even early NSCLC patients,who are evidenced to have no metastasis on imaging and routine pathologic examinations, may have occult metastases, namely, mierometastasis. Mierometastasis is the main cause of death in NSCLC patients at early stage after the radical resection. Therefore, the detection of the micrometastasis of NSCLC patients at the early stage is a new hotspot in the research of lung cancer.