血清VEGF-C在新疆维吾尔族妇女宫颈上皮内瘤变及宫颈鳞癌中的表达及意义

Expressions and significances of serum vascular endothelial growth factor-C in women of Uighur nationality with cervical intraepithelial neoplasia and squamous cell carcinoma of cervix in Xinjiang

目的:探讨新疆维吾尔族妇女宫颈上皮内瘤变(CIN)及宫颈鳞癌患者血清中血管内皮生长因子C(VEGF-C)的含量及其临床意义。方法:应用酶联免疫吸附实验(ELISA)检测VEGF-C在新疆维吾尔族妇女宫颈炎、CIN及宫颈鳞癌患者血清中的含量,并与临床病理参数进行比较。结果:宫颈炎组、CIN组和宫颈癌组的血清VEGF-C含量逐渐增高,其中CIN组高于炎症组,差异有统计学意义(P<0.05);宫颈癌组高于炎症组,差异有统计学意义(P<0.05);但CIN组和宫颈癌组差异无统计学意义(P>0.05)。在宫颈癌患者中临床分期在Ⅰ-Ⅱ期与Ⅲ-Ⅳ期、肿瘤直径>4 cm与≤4 cm以及淋巴结是否有转移的患者血清中VEGF-C的含量比较,差异有统计学意义(P<0.05)。结论:CIN及宫颈鳞癌血清中VEGF-C的含量明显增高,宫颈癌血清中VEGF-C表达水平与临床分期、肿瘤的大小及淋巴结转移呈显著相关,与组织分化程度、肿瘤浸润肌层深度无关。血清VEGF-C含量测定有助于CIN及宫颈鳞癌的辅助诊断及预后判断。

Objective：To explore the contents and clinical significances of serum vascular endothelial growth factor-C（VEGF-C） in women of Uighur nationality with cervical intraepithelial neoplasia（CIN） and squamous cell carcinoma of cervix in Xinjiang.Methods：Enzyme-linked immunosorbent assay（ELISA） was used to detect the contents of VEGF-C in women of Uighur nationality with cervicitis,CIN and squamous cell carcinoma of cervix,and clinicopathological parameters were compared.Results：The serum contents of VEGF-C gradually increased from cervicitis to CIN and squamous cell carcinoma of cervix,and the serum content of VEGF-C in CIN group was significantly higher than that in cervicitis group（P0.05）,the serum content of VEGF-C in squamous cell carcinoma of cervix group was significantly higher than that in cervicitis group（P0.05）;but there was no significant difference between CIN group and squamous cell carcinoma of cervix group（P0.05）;there was significant difference in serum content of VEGF-C between the cases with clinical stage Ⅰ-Ⅱ and the cases with clinical stage Ⅲ-Ⅳ,diameter of tumor4 cm and diameter of tumor4 cm,lymph node metastasis or not（P0.05）.Conclusion：The serum contents of VEGF-C increase significantly in cases with CIN and squamous cell carcinoma of cervix,the expression level of VEGF-C in serum of cases with squamous cell carcinoma of cervix is positively correlated with clinical stages,tumor size and lymph node metastasis,but there is no correlation between expression level of VEGF-C in serum and grades of tissue differentiation and depth of myometrium invasion;detection of serum VEGF-C is helpful for aided diagnosis and predicting prognosis of CIN and squamous cell carcinoma of cervix.