摘要
目的:通过对反复自然流产(RSA)患者和正常早孕妇女绒毛、蜕膜中Survivin、Stat3的测定,探讨不明原因反复自然流产患者的流产病因和胚胎、胎盘的生长机制。方法:采用免疫组化法检测40例RSA患者及20例对照组的绒毛和蜕膜组织中Survivin、Stat3含量。结果:RSA患者孕早期绒毛中Survivin的表达高于对照组,差异有统计学意义(P<0.05),Stat3的表达与对照组差异无统计学意义(P>0.05),二者的表达不存在相关关系(P>0.05);RSA组与对照组蜕膜中Survivin、Stat3的表达差异无统计学意义(P>0.05)。结论:Survivin过表达可能与反复自然流产有关,而Stat3与反复自然流产无关。
Objective：To explore the causes of recurrent spontaneous abortion（RSA） and growth mechanism of embryo and placenta by detecting Survivin and STAT3 in villi and deciduas of patients with RSA.Methods：The expression levels of Survivin and STAT3 in villi and deciduas of 40 patients with RSA and 20 normal early pregnant women（control group） were detected by immunohistochemical method.Results：The expression of Survivin in villi of RSA group was significantly higher than that in control group（P0.05）;there was no significant difference in expression of Stat3 between RSA group and control group（P0.05）;there was no correlation between Survivin expression and Stat3 expression in villi and deciduas（P0.05）.Conclusion：The over-expression of Survivin may be related to RSA,but Stat3 is not correlated with RSA.
出处
《中国妇幼保健》
CAS
北大核心
2011年第1期117-119,共3页
Maternal and Child Health Care of China
基金
河北省人口与计划生育课题〔2008b-07〕
