血清C反应蛋白与临床疾病诊断的关系研究

Serum C-reactive Protein for the Clinical Diagnosis of Diseases

C反应蛋白（CRP）由肝脏合成,能激活中性粒细胞系统和单核-巨噬细胞系统。CRP作为急性时相炎性反应蛋白来诊断或监控炎症时,具有延迟时间短、血清浓度达到峰值以后的半衰期长和对炎性刺激物的敏感度高的特点。CRP浓度升高是任何其他急性时相蛋白的102~103倍。现代技术发展使得测定CRP具有高度的特异度、敏感度、重复性和定量化,还具有操作简便和快速的优点。现主要介绍CRP与一些疾病诊断的相关性。

C-reactive protein（CRP）is synthesized by the liver.CRP can activate the neutral leukocyte and monocyte-macrophage systems.When CRP,an acute-phase protein,should be used for the diagnosis or monitoring of inflammation.It is advantageous in short delay time and long half-life after the serum concentration peak.The sensitivity to inflammation irritants is high.The concentration of CRP increases 102～103 times than other acute phase proteins.Modern technological development makes the determination of CRP highly specific,sensitive,repeatable,and quantifiable.CRP has the additional advantages of simple and fast operation.The article mainly introduces the correlations of CRP with some diseases diagnosis.