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SPA-1通过Rap1信号通路参与疾病的发生和发展

Rap1 Signalling Pathway of SPA-1
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摘要 SPA-1为一种小分子蛋白酶激活蛋白,目前在细胞及肿瘤中研究较多。在细胞中,SPA-1通过与不同的分子或者蛋白相互作用,影响Rap1三磷酸鸟苷酶活性,从而参与细胞功能的调节。在肿瘤方面,SPA-1在乳腺癌和白血病中的研究较多,大量临床研究发现SPA-1与乳腺癌有重要联系,而动物实验发现SPA-1与白血病有关,还发现SPA-1-/-的小鼠部分发生了狼疮样肾小球肾炎,猜测SPA-1在自身免疫疾病中起一定作用。但SPA-1在这些疾病中具体作用机制尚在进一步探索之中。 SPA-1 is a small GTPase-activating protein,mainly studied in cells and tumors at present.In cells,SPA-1 participates in the regulation of cell functions through interacting with different molecules or proteins,promoting Rap1 GTPase activity;SPA-1 also plays an important role in tumor and leukemia.It is involved in breast cancer as documented by extensive clinical studies,as well as leukemia in animal experiments.Mice that are SPA-1deficient develop autoimmune diseases.However,the specific role of SPA-1 in the mechanism of these diseases is still under further exploration.
作者 李敏 冯爱平 苏莉
机构地区 华中科技大学同济医学院附属协和医院皮肤科 华中科技大学生命科学院
出处 《医学综述》 2011年第2期198-201,共4页 Medical Recapitulate
关键词 SPA-1 Rap1 白血病 乳腺癌 自身免疫性疾病 SPA-1 Rap1 Leukemia Breast cancer Autoimmune diseases
分类号 R392.11 [医药卫生—免疫学]
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  • 1Wada Y, Kubota H, Maeda M, et al. Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human [ J]. Genomics, 1997,39 ( 1 ) :66-73.
  • 2Kuraehi H, Wada Y ,Tsukamoto N,et al. Iluman SPA-I gene prod- uct selectively expressed in lymphoid tissues is a specific GTPase- activating protein for Rapl and Rap2. Segeregate expression profiles from a raplGAP gene product [ J ]. J Biol Chem, 1997,272 (44) :28081-28088.
  • 3Ishida D, Kometani K, Hailin Y, et al. Meloproliferative stem cell disorders by deregulated Rapl activation in SPA-1-deficient mice [ J]. C Cell,2003,4( 1 ) :55-65.
  • 4Tsukamoto N, Hattori M, Yang H, et al. Rapl GTPase-activating protein SPA-I negatively regulates cell adhesion [ J ]. J Biol Chem, 1999,274 ( 26 ) : 18463-18469.
  • 5Su L,Hattori M, Moriyama M,et al. AF-6 Controls Integrin-mediated Cell Adhesion by Regulating Rapl Activation through the Specific Recruitment of RaplGTP and SPA-1 [ J]. J Biol Chem,2003, 278(17) :15232-15238.
  • 6Noda Y,Horikawa S, Furukawa T,et al. Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1 [ J ]. FEBS Lett ,2004,568 ( 1/3 ) : 139-145.
  • 7Farina A,Hattori M,Qin J,et al. Bromodomain protein Brdd binds to GTPase-Activating SPA-I, modulating its activity and subcellular localization[ J]. Mol Cell Biol,2004,24(20) :9059-9069.
  • 8Katagiri K,HattoH M,Minato N,et al. Rapl functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses[ J]. Mol Cell Biol,2002,22(4):1001-1015.
  • 9Hara S,Nakaseko C,Yanmsaki S,et al. Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal [ J ]. Hematology, 2009,14 ( 3 ) : 150 -158.
  • 10Maillard I,Tu L, Sambandam A, et al. The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor [ J ]. J Exp Med, 2006, 203 (10) :2239-2245.
医学综述
2011年 第2期

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