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去整合素-金属蛋白酶17与肿瘤的研究进展

The Advances of A Disintegrin and Metallop 17 in the Tumor
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摘要 去整合素-金属蛋白酶17(ADAM17),是一种锌依赖的多结构域Ⅰ型跨膜蛋白,在人类的生长发育过程及炎症和肿瘤等病理过程中起重要作用。研究表明ADAM17在人类多种肿瘤呈高表达,作用机制主要通过水解细胞膜水的多种受体配体的功能而发挥切割转化生长因子α,EGFR-PI3K-Akt信号转导途径及血管的生成等方面来促进肿瘤的发生、进展。 A disintegrin and metallop 17,is a zinc dependent transmembrane type Ⅰ multi-domain protein.It plays an important role in human growth and development process and pathological processes such as inflammation and cancer.Studies have shown that ADAM17 was highly expressed in human tumors.The mechanism of promoten tumorigenesis and progress maybe play cutting transforming growth factor-α,promote EGFR-PI3K-Akt signaling pathway and angiogenesis,etc through hydrolyzing the various membrane receptor ligands.
作者 陈志阳 邢金春
机构地区 厦门第一医院 福建医科大学教学医院泌尿外科
出处 《医学综述》 2011年第2期208-210,共3页 Medical Recapitulate
关键词 肿瘤 去整合素-金属蛋白酶的家族 去整合素-金属蛋白酶17 表皮生长因子 磷酸肌醇激酶 Tumor A disintegrin and metallop roteinase A disintegrin and metallop roteinase17 Epidermalgrowth factor receptor Phosphoinositide 3-kinase
分类号 R737.11 [医药卫生—肿瘤]
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医学综述
2011年 第2期

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