狼疮性肾小球肾炎的病理分类进展

Progress of Pathology Classification of Lupus Glomerulonephritis

为了介绍2003年国际肾脏学协会(ISN)和肾脏病理学协会(RPS)关于狼疮性肾小球肾炎的病理分类,简要地回顾狼疮肾炎(LN)的临床和多种病理特征。2003年ISN/RPS制订的LN病理学分类与过去相比有较大不同,主要去除了Ⅴ型的亚型,不再将完全正常的肾脏列入Ⅰ型外,更加明确和细化了各分型的界定,并依据肾小球病变是节段性或球性对Ⅳ型LN进行再分类,这次分类使观察者之间的重复性大大提高。ISN/RPS关于狼疮性肾小球肾炎的分类已获得广泛的接受,达到了病理变化和临床特征相关联的目标,对诊断、治疗和预后有重要意义。

This article is to introduce the 2003 International Association of Nephrology（ISN）and renal pathology Society（RPS）pathological classification of lupus glomerulonephritis.A brief review of the clinical and a variety of pathological features of lupus nephritis（LN）.The ISN / RPS2003 classification of lupus glomerulonephritis includes multiple changes compared with its predecessors,mainly removal of the subclasses of lupus glomerulonephritis type Ⅴ,no longer be completely normal kidney included in the type Ⅰ,more explicit and detailed the various sub-types definition.Class Ⅳ LN was further subdivided with predominantly glomerulonephritis segmental lesion.This classification will facilitate a higher degree of reproducibility.ISN/RPS on the classification of lupus glomerulonephritis has been widely accepted and achieved the goal related to the correlation of pathology changes and clinical features,which plays an important role in diagnosis,treatment and prognosis.