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前列腺特异抗原相关数据测定在前列腺疾病中的临床应用价值

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摘要 目的分析血清前列腺特异性抗原总量(tPSA)、游离前列腺特异性抗原(fPSA)、fPSA/tPSA与良性前列腺增生(BPH)、前列腺癌的相关性。方法采用化学发光免疫法对健康体检者(正常对照组)、BPH(BPH组)和前列腺癌患者(前列腺癌组)的血清tPSA、fPSA进行检测,比较BPH组和前列腺癌组及正常对照组tPSA、fPSA和fPSA/tPSA各组指标的差异,分析各指标的诊断特异性及敏感性。结果正常对照组tPSA/fPSA为0.35±0.14;BPH组fPSA/tPSA为0.27±0.15;前列腺癌组fPSA/tPSA为0.10±0.06。当fPSA/tPSA临界值取0.16时,诊断前列腺癌的灵敏度为87.7%,特异性为79.7%。结论当tPSA在诊断灰区时,fPSA/tPSA可提高前列腺癌的诊断特异性及敏感性,可作为前列腺癌的辅助诊断指标,对其诊断及预后的监测中具有较高的临床应用价值。
出处 《河北医药》 CAS 2011年第4期562-563,共2页 Hebei Medical Journal
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参考文献5

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