多索茶碱对慢性阻塞性肺疾病炎性递质的影响

Influence of doxofylline on inflammatory mediators in chronic obstructive pulmonary disease

目的观察并比较多索茶碱与氨茶碱治疗慢性阻塞性肺疾病的临床疗效及安全性。方法将126例慢性阻塞性肺疾病患者随机分为A组64例和B组62例。在常规治疗的基础上,A组给予多索茶碱300 mg每天1次,B组给予氨茶碱250 mg每天1次,观察2组慢性阻塞性肺炎患者肺部哮鸣音、喘息症状、血气分析主要指标以及炎性递质的变化情况。结果 A组临床总有效率显著高于B组(P<0.05)。与B组比较,A组治疗后血气分析主要指标改善更好,炎性递质水平下降更明显(P均<0.05)。结论多索茶碱治疗慢性阻塞性肺炎较氨茶碱安全、有效;可作为慢性阻塞性肺炎治疗方案的首选。

Objective It is to observe and compare the clinical effect and safety of doxofylline and aminophylline in treatment of chronic obstructive pulmonary disease （COPD）. Methods 126 patients with COPD were randomly divided into Group A with 64 patients and Group B with 62 cases. On the basis treatment of COPD, Group A was treated with doxofylline for 300 mg once-daily, Group were given aminophylline for 250 mg once-daily. The pneumonia and chronic obstructive pulmonary wheeze and wheezing symptoms, the changes of key indexes of arterial blood gas analysis and the inflammatory mediators were observed in both groups. Results The clinical total effective rate of Group A was higher than that of Group B, there was significantly difference （ P 〈 0.05 ）. Compared with Group B, the blood gas analysis of key indexes were improved significantly, and the levels of inflammatory mediators were decreased significantly （ all P 〈 0.05 ）. Conclusion Doxofylline is effective and safe than aminophylline in treatment of COPD; it can be used as the first choice in treatment of COPD.