氟比洛芬酯联合曲马多用于乳腺癌术后镇痛效果分析

The application of flurbiprofen axetil associated with tramadol on postoperative analgesia after modified radical mastectomy

目的观察氟比洛芬酯联合曲马多用于乳腺癌改良根治术后镇痛的效果。方法 40例乳腺癌改良根治术患者随机分为F、FD组,每组20例。F组诱导前静脉注射氟比洛芬酯50mg,FD组诱导前静脉注射氟比洛芬酯50mg,缝皮前静脉注射曲马多50mg。观察气管拔管后1、2、4、8、24h的视觉模拟评分(VAS)及不良反应。结果 FD组VAS评分在各时点均低于F组。结论氟比洛芬酯联合曲马多,可提高镇痛质量,是乳腺癌改良根治术后镇痛的良好选择。

Objective To determine the effect of flurbiprofen axetil associated with tramadol on postoperative analgesia after modified radical mastectomy. Methods Forty patients scheduled to undergo modified radical mastectomy were randomly divided into groups F and FD.The patients received flurbiprofen axetil 50 mg before anesthesia induction in two groups and tramadol 50 mg before suture skin in FD group.The effects of analgesia after operation were assessed by visual analogue scale（VAS）at 1,2,4,8,24 hours after tracheal extubation,side effects were also assessed.Results The VAS of group FD was lower than group F during 24 hours after tracheal extubation.Conclusion Flurbiprofen axetil associated with tramadol can increase the quality of postoperative analgesia,and is a good choice for the patients after modified radical mastectomy.