病房葡萄球菌感染与耐药性分析

The change on resistance of the Staphylococcus inpatient

目的了解我院葡萄球菌感染与耐药情况,为临床防治葡萄球菌感染提供依据。方法对2005年1月—2009年12月病房所分离到的葡萄球菌耐药性进行回顾性调查。结果共分离获得金黄色葡萄球菌139株,凝固酶阴性葡萄球菌253株,检出株数在逐年增加。体外药敏试验结果显示红霉素、克林霉素、庆大霉素、四环素、左氧氟沙星对金黄色葡萄球的耐药率在逐年上升。凝固酶阴性葡萄球菌则对克林霉素耐药率逐年上升。结论我院每年金黄色葡萄球检出株数有逐年增高的趋势,耐药率在升高,同时由凝固酶阴性葡萄球引起的感染也不容忽视,应高度重视并采取措施预防院内感染,减少多重耐药率的产生。

Objective To study the change on resistance of Staphylococcus,for the guidance of rational use of antibacterials.Methods To collect data of the Staphylococcus from clinical specimen from Jan 2005 to Dec 2009 and make analyses on the drug sensitivity test.Results There were 139 cases with S.aureus and 253 cases with coagulase-negative Staphylococcus infection in the past five years.The resistance rates of S.aureus to erythromycin,clindamycin,gentamici,tetracycline and evofloxacin were increased.The resistance rate of coagulase-negative to gentamici were increased. Conclusion The percentage of S.aureus and coagulase-negative Staphylococcus are increasing yearly.There was an elevated tendency of the resistance rates to common antibacterial for past five years.The main isolates are aI1 multi-drug resistant.