肾移植急性排斥前后血清CRP、IL-1β及TNF-α的表达变化

Expression of CRP,IL-1β,TNF-α before and after acute rejection following rebal transplantation

目的:探讨肾移植前后血清中CRP,IL-1,βTNF-α的水平与移植术后急性排斥反应的关系。方法:将54例肾移植患者分为术后稳定组,急性排斥反应组及抗排斥逆转组,采用酶联免疫吸附(EL ISA)法动态监测移植前后血清CRP,IL-1,βTNF-α水平。结果:急性排斥反应组CRP,TNF-α及IL-1β表达显著高于术后稳定组(P<0.01),而术后稳定组与抗排斥治疗逆转组之间无显著性差异(P>0.05)。结论:对肾移植受者外周血CRP,IL-1,βTNF-α进行监测,可反映肾移植受者的免疫反应状态,并为排斥反应的监测和诊断提供客观依据。

Objective： To investigate the association of per-and-post-transplant serum content of CRP,IL-1β,TNF-α for kidney transplantation recipients and acute rejection.Methods： Per-and-post-transplant serum content of CRP,IL-1β,TNF-α for 54 case with kidney transplantation recipients was tested using a commercialable enzyme linked immunosorbent assay（ELISA）.54 patients（76 specimens） were divided into 3 groups：patients with a stable graft function（group 1）,patients with acute rejection（group 2）,patients recovered after an anti rejection therapy（group 3）.CRP,IL-1β,TNF-α,expression of ever group were compared with a student test.Results：The level of CRP,TNF-α and IL-1β in group 2 were significantly higher than those in the other 2 groups,and there were no significant differences between group 1 and 3.Conclusion： The levels of CRP,IL-1β,TNF-α may reflect status of immune respones in renal allograft recipients,which will provide evidence for the monitoring and diagnosis of acute rejection.