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大鼠耳蜗背核神经元第一动作电位延时的特性

The Characteristics of the First Spike Latency in the Rat Dorsal Cochlear Nucleus
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摘要 目的:探讨大鼠耳蜗背核神经元第一动作电位延时的特性。方法:采用在体细胞外记录方法,通过给予单耳不同频率和声强的短纯音刺激,记录成年SD大鼠耳蜗背核神经元反应,并分别以动作电位发放数(spike counts,SC)和第一动作电位延时(first spike latency,FSL)为评价指标,分析比较它们对同一刺激的反应稳定性。结果:共记录到21个单单位(single-unit)神经元反应。这些神经元均以burst spikes这种多放电率的形式发放。以发放数为评价指标,这些神经元分别表现出单调(76%)、饱和(19%)和非单调(5%)三种声强反应。而第一动作电位延时展示出同一规律的FSL-声强反应曲线:FSL随着声强的增大而缩短。SC-频率曲线呈现多形性,而FSL-频率曲线呈"V"字型。结论:在大鼠耳蜗背核神经元,相比发放数,第一动作电位延时对同一刺激的反应稳定性更好。 Objective： To evaluate the characteristics of the first spike latency in the rat dorsal cochlear nucleus.Methods： Using extracellular recording methods,we recorded the dorsal cochlear nucleus on adult SD rats by giving unilateral ear at different frequencies and intensities stimulation.Both Spike counts（SC） and First spike latency（FSL） were evaluated,then comparing their stability to the same stimuli.Results： A number of 21 single-unit neurons were recorded.SC-amplitude functions are classified as the monotonic（76%）,saturated（19%） and non-monotonic（5%）.While FSL show the same regular FSL-Amplitude functions：FSL reduced monotonically with the increace of amplitude.SC-Frequency curves show pleomorphism,while FSL-Frequency function display the shape of ＂V＂.Conclusion： Compared with spike counts（SC）,First spike latency（FSL） can display the response of acoustic stimulation better in the rat dorsal cochlear nucleus.
作者 刘萍 熊铁根 傅鸣宇 肖中举
机构地区 广州南方医科大学生理学教研室 广州市三九脑科医院神经内科
出处 《数理医药学杂志》 2011年第1期28-32,共5页 Journal of Mathematical Medicine
基金 国家自然科学基金项目(30670665 30730039 30570571)
关键词 第一动作电位延时 发放数 在体细胞外记录 耳蜗背核 first spike latency spike counts extracelluar recording dorsal cochlear nucleus
分类号 R339.16 [医药卫生—人体生理学]
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参考文献18

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数理医药学杂志
2011年 第1期

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