优泌乐50强化治疗对初诊2型糖尿病胰岛功能及炎症因子的影响

The influence of short-term intensive insulin therapy on β-cell function and inflammatory factor in newly diagnosed type 2 diabetes

目的探讨优泌乐50强化治疗对初诊2型糖尿病(T2DM)胰岛β细胞功能及高敏C反应蛋白(hs-CRP)的影响。方法 40例新诊断T2DM患者,应用优泌乐50强化治疗2周,分析治疗前后空腹血糖(FPG)、餐后2 h血糖(P2hPG)、空腹胰岛素(FINS)、精氨酸刺激试验后胰岛素增值(△INS)、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-IS)以及hs-CRP的变化。结果治疗2周,FPG、P2hPG、HOMA-IR及hs-CRP明显降低(P<0.05或P<0.01),△INS和HOMA-IS明显升高(P<0.01)。相关分析显示hs-CRP与△INS、HOMA-IS呈负相关,与HOMA-IR呈正相关。结论对显著高血糖初诊T2DM患者应用优泌乐50短期强化治疗可快速降低血糖,控制慢性炎症样反应,有效保护胰岛β细胞功能。

Objective To observe the influence of short-term intensive mixed protamine zinc recombinant human insulin lispro injection（50R）therapy on β-cell function and hs-CRP in newly diagnosed T2DM.Methods 40 newly diagnosed T2DM patients were given the intensive insulin therapy for 2 weeks.The change of FPG,P2hPG,FINS,△INS,HOMA-IS,HOMA-IR and hs-CRP before and aftertherapy were measured.Results After intensive therapy,FPG、P2hPG、HOMA-IR and hs-CRP were significantly lower than before（P0.05 or P0.01）,△INS and HOMA-IS were increased significantly（P0.01）.It was showed that hs-CRP was negatively correlated with △INS and HOMA-IS（P0.01）,and positively correlated with HOMA-IR（P0.01）.Conclusions Short-term intensive therapy may decreased blood glucose quickly,control their chronic inflammation reaction,and proted cell function effectively in newly-diagnosed T2DM.