青霉素萃取工艺条件研究

Study on technical conditions of penicillin extraction

对青霉素萃取理论模型进行研究，并作了大量的实验研究，发现传统的青霉素萃取工艺条件（ｐＨ＝ １．８～２．２，温度为５ ℃，相比ＶＯ／ＶＷ ＝ １／２～１／２．５，采用两级萃取）不是最佳的。提出了新的萃取操作工艺条件，即ｐＨ＝ ３．０±０．２，温度为常温２０ ℃，相比ＶＯ／ＶＷ ＝ １／３～１／４，并采用三级萃取以保证萃取率。实验证明，提高萃取的ｐＨ 值，有利于萃取体系选择性的提高，可以减小青霉素的损失； 提高萃取温度将极大地降低能耗； 适当降低萃取相比，有利于提高产品质量，减少对杂酸的萃取。

Based on the study of the theory model of penicillin extraction and experiment results, it is found that the traditional technical condition of penicillin extraction (pH=1.8~2.2, 5℃, V O/ V W=1/2~1/2.5, two stage countercurrent extraction) is not the best choice. A new operation condition is presented, that is pH=3.0±0.2, 20℃, V O/ V W=1/3~1/4, three stage countercurrent extraction. The experiment results show that, it is benefit for the selectivity and yield rate to raise the pH value; raising the temperature can cut down the energy cost; the quality of the product is improved and the extraction of impure acid is decreased by reducing the phase ratio.