摘要
目的分析2型糖尿病患者糖化血红蛋白(HbA1c)与甲状腺激素水平的相关性,探讨长期血糖控制对糖尿病甲状腺功能影响的临床意义。方法采用化学发光法检测2型糖尿病及健康对照组游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、超敏促甲状腺素(S-TSH),使用高效液相色谱仪分析HbA1c,同时分析受试者空腹血糖(FBG)。结果 2型糖尿病组FT3低于正常对照组(P<0.01),S-TSH高于对照组(P<0.01),FT4低于对照组,但差异无显著性(P>0.05);2型糖尿病患者FBG与HbA1c量成正相关(P<0.01),HbA1c与FT3浓度成负相关(P<0.05)。结论 2型糖尿病患者甲状腺激素水平紊乱增多且与长期高血糖相关。
Objective To investigate the effects of longterm control of blood sugar in patients with type 2 diabetes mellitus by analyzing the correlation of the levels of glycosylated hemoglobinAlc (HbAlc) and thyroid hormone. Methods A chemiluminescence method was used to determine the serum concentrations of FT3, FT4 and S - TSH in patients with type 2 diabetes mellitus and in healthy control group. Meanwhile a High Performance Liquid Chromatography (HPLC) was used to analyze the glycosylated hemoglobinAlc (HbAlc) and the fasting blood glucose (FBG) in patients with type 2 diabetes mellitus (type 2 diabetes mellitus group) and in healthy control group. Results In the type 2 diabetes mellitus group, FT3 lowered, there was statistically significant difference ( P 〈 0.01), compared t9 the control group, S-TSH was higher than those in the control group ( P 〈 0.01), and the FT4 was lower, but there was no statistical difference, conpared to those in the control group ( P 〉0.05). In patients with type 2 diabetes mellitus, FBG is positively associated with the concentrations of HbAlc ( P 〈 0.01), and is negatively associated with FT3 ( P 〈0.05). Conclusion The serun levels of thyroid horme disorder improves and is related to longterm high blood sugar in patients with type 2 diabetes mellitus.
出处
《右江民族医学院学报》
2011年第1期11-13,共3页
Journal of Youjiang Medical University for Nationalities
关键词
2型糖尿病
甲状腺激素类
血红蛋白A
糖基化
diabetes mellitus, type 2
thyroid hormones
hemoglobin A, glycosylated