2型糖尿病患者糖化血红蛋白与甲状腺激素水平分析

The analysis of the correlation of the levels of glycosylated hemoglobin A1c and thyroid hormone in patients with type 2 diabetes mellitus

目的分析2型糖尿病患者糖化血红蛋白(HbA1c)与甲状腺激素水平的相关性,探讨长期血糖控制对糖尿病甲状腺功能影响的临床意义。方法采用化学发光法检测2型糖尿病及健康对照组游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、超敏促甲状腺素(S-TSH),使用高效液相色谱仪分析HbA1c,同时分析受试者空腹血糖(FBG)。结果 2型糖尿病组FT3低于正常对照组(P<0.01),S-TSH高于对照组(P<0.01),FT4低于对照组,但差异无显著性(P>0.05);2型糖尿病患者FBG与HbA1c量成正相关(P<0.01),HbA1c与FT3浓度成负相关(P<0.05)。结论 2型糖尿病患者甲状腺激素水平紊乱增多且与长期高血糖相关。

Objective To investigate the effects of longterm control of blood sugar in patients with type 2 diabetes mellitus by analyzing the correlation of the levels of glycosylated hemoglobinAlc （HbAlc） and thyroid hormone. Methods A chemiluminescence method was used to determine the serum concentrations of FT3, FT4 and S - TSH in patients with type 2 diabetes mellitus and in healthy control group. Meanwhile a High Performance Liquid Chromatography （HPLC） was used to analyze the glycosylated hemoglobinAlc （HbAlc） and the fasting blood glucose （FBG） in patients with type 2 diabetes mellitus （type 2 diabetes mellitus group） and in healthy control group. Results In the type 2 diabetes mellitus group, FT3 lowered, there was statistically significant difference （ P 〈 0.01）, compared t9 the control group, S-TSH was higher than those in the control group （ P 〈 0.01）, and the FT4 was lower, but there was no statistical difference, conpared to those in the control group （ P 〉0.05）. In patients with type 2 diabetes mellitus, FBG is positively associated with the concentrations of HbAlc （ P 〈 0.01）, and is negatively associated with FT3 （ P 〈0.05）. Conclusion The serun levels of thyroid horme disorder improves and is related to longterm high blood sugar in patients with type 2 diabetes mellitus.