XPF基因Arg415Gln多态性与癌症易感性关联的Meta分析

A meta-analysis of the association of XPF genes 415Gln polymorphisms with cancer susceptibility

目的已有的研究结果显示DNA修复基因XPF Arg415Gln多态位点与癌症发生存在相关性,但研究结果尚未有一致性结论。笔者旨在通过meta分析的方法,综合评价DNA修复基因XPF Arg415Gln多态位点与癌症发病风险的相关性。方法检索中国生物医学数据库CBM、PubMed、OVID等数据库,获取有关XPF Arg415Gln多态性同癌症易感性关系的病例对照研究并进行Meta分析,应用Meta分析软件对各研究原始数据进行统计处理及异质性检验,计算合并OR值及其95%可信区间(95%CI)。结果最后本研究共纳入文献7篇,XPF Arg415Gln多态性累积病例4799例,对照6212例,Meta分析结果显示XPF Arg415Gln各基因型与癌症的风险性无统计学意义。此外,依据癌症种类还进行乳腺癌XPF Arg415Gln亚组分析结果发现,XPF Arg415Gln在乳腺癌中的发病风险性无显著相关。结论 XPF Arg415Gln多态性与癌症之间易感性无显著相关性。但需增加样本量,提高研究质量进一步研究。

Objective All the studied indicated that the association of the DNA repaired genes XPF Arg415Gln polymorphisms with cancer susceptibility, but the studied results did not draw a conclusion. To explore whether thepolymorphisms of XPF Arg415Gln contribute to the susceptibity with cancer, we carried a meta - analysis based on the published works. Methods The literatures eligible from CBM, PubMed and OVID databse were enrolled in the meta- analysis. The pooled OR and 95 % CI, and the heterogenicity test were caculated by RevMan4.2 software. Results This study included 7 literatures. There were 4799 cases in XPF 415Gln polymorphism group, and the controls 6212 cases. Overall, meta - analysis results showed that there were no statitically slgnificnt differences of the association between the XPF 415Gln polymorphism and the cancer susceptibility. In addition, according to the types of cancer, subgroup meta-analysis showed no significnt difference between XPF 415Gln polymorphism and the susceptibility attack risk of breast cancer. Conclusion The correlation between XPF 415Gln polymorphism and cancer susceptibility were not significant. Big samples still needed to further study.