酒精中毒与急性胰腺炎的相关性分析

The correlation analysis of alcoholism and acute pancreatitis

目的分析酒精中毒与急性胰腺炎(AP)的相关性。方法收集2004年4月—2009年10月收治的213例AP病例,其中78例为酒精相关性胰腺炎(观察组),135例为胆源性、高脂血症、暴饮暴食等其他病因引起的非酒精相关性胰腺炎(对照组),对2组进行回顾性对比分析。结果观察组中男性构成比明显高于对照组(P<0.01),急性重症胰腺炎(SAP)的发生率及病死率均高于对照组(P<0.01)。观察组的APACHEⅡ评分、血糖、C反应蛋白(CRP)及急性呼吸窘迫综合征(ARDS)、肝功能不全、心功能不全、肾功能衰竭、胰性脑病的发生率明显高于对照组(P<0.05,P<0.01)。结论酒精相关性胰腺炎以男性为主,其更易发展为重症胰腺炎,并发症多,病死率高,早期诊断、及时进入ICU采取综合救治是抢救成功的关键。

Objective To analyze the correlation of alcoholism and acute pancreatitis.Methods Collected 213 patients of acute pancreatitis（AP） from Apr 2004 to Oct 2009.The acute alcoholic pancreatitis were 78 samples（observation group）;The rest were pancreatitis with reasons of cholelithiasis,hyperlipemia,binge overeating and others（control group）. Retrospective comparative analysis was employed in two groups.Results The constituent ratio of male in observation group was obviously higher than that in control group（P0.01）;The incidence rate of severe acute pancreatitis（SAP） and fatality rate in observation group was obviously higher than that in control group（P0.01）.The APACHEⅡgrading,blood sugar, C reactive protein（CRP） and the incidences rate of acute respiratory distress syndrome（ARDS）,hepatic insufficiency,cardiac insufficiency,renal failure and encephalopathy in observation group was obviously higher than the incidences in control group （P0.05,P0.01）.Conclusion It demonstrated that the acute alcoholic pancreatitis was predominant in male,and was reliable progressive to SAP,fatality rate was high.Early diagnosis and combination treatment in ICU were the keys to rescue successfully.