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二甲双胍在老年2型糖尿病患者治疗中的作用 被引量:4

Role of metformin in elderly patients with type 2 diabetes mellitus
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摘要 二甲双胍(Metformin)自1957年上市以来,已经在治疗糖尿病的征途上风风雨雨走过了50多年。实际上.早在一个世纪前科学研究者就在对山羊豆素样化合物的合成和药理学研究中发现了二甲双胍.但由于胰岛素和磺脲类药物的发现和使用,
作者 袁群
出处 《药品评价》 CAS 2011年第1期18-22,共5页 Drug Evaluation
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  • 1Hundal HS, Ramlal T, Reyes R, et al. Mechanism by which metformin reduces glucose production in type 2 diabetes[J]. Diabetes, 2000, 49: 2063-2069.
  • 2De Aguiar LG, Bahia LR, Villela N, et al. Metformin improves endothelial vascular reactivity in first-degree relatives of type 2 diabetic patients with metabolic syndrome and normal glucose tolerance[J]. Diabetes Care, 2006, 29(5): 1083-1089.
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  • 4UK Prospective Diabetes study (UKPDS) Group. Effect of intensive bloodglucose control with metformin on complications in overweight patients with type 2 diabetes CUKPDS 34)[J].Lancet, 1998, 352: 854-865.
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