参芎注射液联合七叶皂苷钠治疗急性胰腺炎的临床观察

The treatment of acute pancreatltis with Shenxiong injection combined with aescinate

目的 了解参芎注射液及七叶皂苷钠对急性胰腺炎（AP）患者血浆内皮素浓度的影响及其改善微循环的作用.方法 将87例AP患者完全随机分为对照组20例、单用组33例、联合组34例.3组均采用常规治疗,单用组加用参芎注射液治疗,联合组加用参芎注射液和七叶皂苷钠治疗,观察各组腹痛、腹部压痛、血尿淀粉酶及内皮素等变化情况.结果 单用组和联合组腹部压痛消失、肠道功能恢复、血尿淀粉酶和影像学恢复时间及平均治疗时间均短于对照组（P＜0.05）;联合组肠道功能恢复、血尿淀粉酶和影像学恢复时间及平均治疗时间均短于单用组（P＜0.05）.单用组和联合组患者治疗后血浆内皮素浓度[（64.79±7.58）ng/L、（47.80±7.14）ng/L]明显低于治疗前[（104.77±6.57）ng/L、（103.41±7.53）ng/L]（P＜0.05）.结论 在常规治疗的基础上联合应用参芎注射液、七叶皂苷钠治疗AP具有良好的临床疗效,值得临床推广.

Objective To study clinical effects of Shenxiong injection and aescinate in the treatment of acute pancreatitis,and to understand the effect of Shenxiong injection and aescinate on the concentration of plasma endothelin（ET） in patients with acute pancreatitis（AP）. Methods Eighty-seven cases of AP patients were randomly divided into group A（20 cases） and the control group B（33） and group C（34）. A group had conventional therapy,B group had the conventional treatment plus Shenxiong injection and C group had conventional treatment plus Shenxiong injection and aescinate. The plasma concentrations of ET were mensurated with radiation immunoassay（RIA）. Results The pain disappearance time had no significant difference（P 〉0.05） among the three groups.The time of abdominal tenderness disappearance,intestinal function recovery,hematuria amylase recovery,imaging recovery and average hospitalization were shorter in B group and in C group than those in control group（A group）（P 〈0.05）. The plasma ET concentrations after treatment were significantly lower than that before treatment in group B and C（P〈0.05）. Conclusions The therapy based on the conventional treatment combined with Shenxiong injection and aescinate has good curative effect in patients with acute pancreatitis.