抑郁症患者血清同型半胱氨酸水平的研究

Study on the levels of serum homocysteine in the patients with depressive disorder

目的探讨抑郁症患者血清同型半胱氨酸水平与抑郁症发病的相关性。方法将94例抑郁症患者作为研究组,选取98例身心健康正常人为对照组,应用荧光偏振免疫法检测血清同型半胱氨酸水平。结果研究组患者血清同型半胱氨酸水平显著高于对照组(16.72±3.94)μmol/L,(10.99±3.51)μmol/L,P<0.05,研究组高同型半胱氨酸血症发生率显著高于对照组(41.5%,14.3%)(χ2=14.89,P<0.05)。结论血清同型半胱氨酸水平升高可能是抑郁症发病的重要危险因素之一,血清同型半胱氨酸水平对抑郁症严重程度有一定的影响。

Objective To investigate the serum levels of homocysteine in patients with depressive disorder,and the relationship between serum homocysteine levels and depressive symptoms.Methods A total of 94 patients with depressive disorder in study group and 98 normal health controls in control group were co1ected in this study.The serum levels of homocysteine were determined by fluorescence polarization immunoassay（FPIA）.The 24-item Hamilton rating scale for depression（HAMD）was used to evaluate depressive symptoms.Results The serum homocysteine 1evel was significantly higher in study group than that in control group（（16.72±3.94）μmol/L,（10.99±3.51）μmol/L;P0.05）.The rate of hyperhomocysteinemia（HHcy）in study group was significantly higher than that in control group（χ2=14.89,P0.05）.In study group,the score of HAMD was significantly positively related to serum homocysteine 1eve1（r=0.611）.The score of HAMD in patients with HHcy was significantly higher than that in patients without HHcy（t=6.193,P0.05）.Conclusion The increase of serum homocysteine 1evels maybe play an important risk factor in the pathogenic mechanism of depressive disorder,and the serum homocysteine level could influence severity of depression.