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HO-1与γ-GCS在COPD大鼠肺组织中的表达及大蒜素的治疗作用 被引量：1

The expression of HO-1 and γ-GCS in COPD rats lung tissue and the treatment function of Allicin
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摘要 目的探讨HO-1、γ-GCS在慢性阻塞性肺疾病发病机制中的作用及观察大蒜素的治疗干预作用。方法香烟熏吸加气管内滴入脂多糖制作COPD模型,将30只Wistar大鼠随机分成COPD组、对照组和大蒜素干预组,采用免疫组化法检测HO-1、γ-GCS在各组大鼠中的表达。结果各组之间HO-1、γ-GCS表达强度分别有显著差异(P<0.01),且呈正相关。结论γ-GCS反应性表达增高是COPD抗氧化主要机制之一;HO-1的表达影响γ-GCS的表达;大蒜素通过增加肺组织中HO-1、γ-GCS的表达而有一定的COPD治疗作用。 Objective To study the roles of HO-1 and γ-GCS in chronic obstructive pulmonary disease（COPD）,and to explore the intervention of the Allicin.Methods COPD rat models were established by smoking as well as intratracheal instillation lipopolysaccharide（LPS）.Wistar rats were randomly divided into three groups,COPD group,Allicin group,normal control group.The expressions of HO-1 and γ-GCS in the lung tissule were detected by immunhistochemistry.Results Among the groups,the expressions of HO-1,γ-GCS were significantly different（P0.01） and positively correlated.Conclusion γ-GCS expression increased reactivity is the main mechanism of antioxidant COPD;The expression of HO-1 affect expression of γ-GCS;Allicin may increase the expression of HO-1,γ-GCS in Allicin rat models,and may play an important role in the treatment of COPD.
作者 高崴崴 夏熙郑
机构地区 郑州大学第二附属医院呼吸内科
出处 《中国现代医药杂志》 2011年第1期22-24,共3页 Modern Medicine Journal of China
关键词 血红素加氧酶1 Γ-谷氨酰半胱氨酸合成酶 COPD大鼠 大蒜素 HO-1 γ-GCS COPD rats Allicin
分类号 R285 [医药卫生—中药学]
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参考文献8

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共引文献258

同被引文献10

  • 1熊丽红,于亮,李冰,冉丕鑫.大蒜素对大鼠肺泡上皮细胞γ谷氨酰半胱氨酸合成酶表达的影响[J].中华结核和呼吸杂志,2006,29(6):368-371. 被引量：5
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中国现代医药杂志
2011年 第1期

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