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帕瑞昔布钠联合舒芬太尼治疗术后急性疼痛的效果

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摘要 瑞芬太尼是目前广泛用于术中持续静脉输注的超短效阿片类镇痛药物,其起效快、作用时间短、停药后患者苏醒彻底。但同时由于其代谢迅速、作用时间短并可能诱发痛觉过敏,所以患者在苏醒后可能出现急性剧烈疼痛[1~3],而帕瑞昔布钠是选择性环氧化酶-2抑制剂,通过抑制前列腺素等的合成发挥强效镇痛及抑制痛觉敏感的作用[4]。
作者 辛兢
出处 《中国现代医药杂志》 2011年第1期84-85,共2页 Modern Medicine Journal of China
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  • 1Guignard B,Bossard AE, Coste C, et al. Acute opioid tolerance:intraoperative remifentanil increases postoperative pain and mor- phine requirement. Anesthesiology,2009,93(2):409-417.
  • 2Hanse EG, Duedahl TH, Romsing J, et al. intra-operative remifentanil mint influence pain level in the immediate post-operative period after abdominal surgery. Acta Anaesthesiol Acand, 2005,49(10):1464-1470.
  • 3许康清.冯霞.手术期麻醉药物治疗学.北京:人民卫生出版社,2003:133.
  • 4Tirauh M, Derrode N, Clevenot D, et al. The effect of nefopam on morphine overconsumption induced by large-dose remifentanil during propofol anesthesia for major abdominal surgery. Anesth Analg,2006,102(1 ): 110-117.
  • 5Buvanendran A, Kroin JS, Berger RA, et al. Upregulation of prostaglandin E2 and interleukins in the central nervous system and peripheral tissue during and after surgery in humans. Anesthesiology, 2006,104(3):403-410.
  • 6Reuben SS,Buvanendran A,Kroin JS,et al. Postoperative modulation of central nervous system prostaglandin E2 by cyclooxygenase inhibitiors after vascular surgery.Anesthesiology,2006,104(3):411- 416.
  • 7Reuben SS, Ekman EF, Raghunathan K, et al.The effect of yclooxygenase-2 inhibition on acute and chronic donor-site pain after spinal-fusion surgery. Reg Anesth Pain Med,2006,31:6-13.
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