探讨胃癌术后患者生存的影响因素

Study of prognostic factors of operated gastric cancer

目的探讨胃癌术后患者性别、年龄、肿瘤TNM分期、是否化疗、术前肿瘤标志物表达情况与预后的关系。方法选取2008年6月至2009年6月收治的首次入院并行手术治疗的胃腺癌患者125例,对可能影响生存的因素进行统计分析,选择性别、年龄、肿瘤TNM分期、是否化疗、术前肿瘤标志物表达等指标,用单因素和多因素分析的方法研究其对生存的影响。应用SPSS16.0统计软件进行数据处理,采用Kaplan-Meier法、COX比例风险回归模型进行分析。结果单因素分析中:肿瘤TNM分期、术前癌胚抗原(CEA)、CA199、CA242、CA724均为胃癌术后患者生存的影响因素。将上述诸相关参数进行COX比例风险回归模型分析,得出肿瘤TNM分期、术前CA199水平是影响胃癌术后患者生存的独立因素,按其作用大小依次排序为:肿瘤TNM分期、CA199。结论肿瘤TNM分期、术前CA199水平是影响胃癌术后患者生存的独立因素。

Objective To investigate the relationship between the features（sex,age,TNM staging,chemotherapy,tumor marker） and prognosis of gastric cancer.Methods Clinical data of 125 patients with primary gastric cancer who were first time in hospital between 2008 and 2009.To select sex,age,TNM staging,chemotherapy and tumor marker as observed factors and to investigate the relationship between them and prognosis of gastric cancer.Statistical calculations were performed using SPSS 16.0.The statistical methods were Kaplan-Meier and COX proportional hazard model.Results In single factor analysis： TNM Staging and tumor markers（CEA,CA199,CA242,CA724） were influencing factors about prognosis of gastric cancer.In multiple factor analysis： TNM staging and CA199 were independent influencing factor.Conclusion TNM staging and CA199 were independent influencing factor of operated gastric cancer.