氨基末端脑钠肽原及TNF-α与冠心病的相关性研究

Study of the association of NT-proBNP and TNF-α levels with the extent of coronary artery disease

目的:探讨血浆中的氨基末端脑钠肽原(NT-proBNP)及肿瘤坏死因子α(TNF-α)水平与冠状动脉粥样硬化性心脏病(冠心病)的相关性。方法:入选冠心病患者120例,根据冠心病类型分为稳定型心绞痛组、不稳定型心绞痛组及急性心肌梗死组,35例冠状动脉造影正常的受试者作为对照组,比较不同病变组及对照组之间的NT-proBNP及TNF-α水平的差异;同时按照冠状动脉血管病变的数目,将冠心病患者分为单支病变组、双支病变组、三支病变组,比较病变支数与NT-proBNP和TNF-α的相关性。结果:本研究表明NT-proBNP及TNF-α在对照组、稳定型心绞痛组、不稳定型心绞痛组及急性心肌梗死组间存在明显差异,此外TNF-α水平与冠状动脉血管病变支数存在显著性相关;但是NT-proBNP血浆水平与病变支数无显著性相关。结论:NT-proBNP及TNF-α可以作为反映冠状动脉病变程度的重要指标。

Objective： To study the association of N-terminal pro-brainnatriuretic peptide（NT-proBNP）,tumor necrosis factor-α（TNF-α） levels and the extent of coronary artery disease（CAD）.Methods：One hundred and twenty CAD patients and thirty-five non-CAD pa-tients were included in this study.All of the subjects were verified with coronary angiography.In the light of the types of CAD,CAD patients were assigned into three groups（SAP group,UAP group,AMI group）,the comparisons of NT-proBNP and TNF-α levels were performed among the SAP,UAP,AMI and non-CAD groups.According to the number of suffered coronary artery,CAD pa-tients were divided into groups of single-vessel,double-vessel and three-vessel.The associations of the levels of NT-proBNP and TNF-α with CAD severity were also evaluated.Results：We found a significant association between the types of CAD and changes of NT-proBNP or TNF-α level.We also observed that change of TNF-α,not NT-proBNP,was significantly associated with the number of vessels of suffered coronary artery.Conclusion：NT-proBNP and TNF-α may be useful markers of the extent of CAD.