期刊文献+

甲氨蝶呤联合得宝松关节腔注射治疗炎性关节病 被引量:2

下载PDF
导出
摘要 目的探讨甲氨蝶呤(MTX)联合得宝松关节腔注射治疗类风湿性关节炎(RA)和脊柱关节病(SPA)的疗效。方法采用随机分组临床试验。试验组21例,采用关节腔一次性注射10 mg MTX+5 mg得宝松;对照组21例常规使用免疫抑制剂柳氮磺吡啶(SASP)+MTX或MTX+来氟米特,两组均口服非甾体抗炎药。结果试验组和对照组治疗前后临床症状有显著改善,实验室炎性指标ESR和CRP显著下降。结论甲氨蝶呤联合得宝松关节腔注射治疗炎性关节病作用快,效果好。
出处 《安徽医学》 2011年第1期67-68,共2页 Anhui Medical Journal
  • 相关文献

参考文献5

二级参考文献10

  • 1戴华,王强,刘实.小剂量甲氨蝶呤对类风湿关节炎的治疗[J].中国药物与临床,2004,4(7):530-531. 被引量:4
  • 2Cawston T.Matrix metalloproteinases and TIMPs:properties and implications for the rheumatic diseases[J].Mol Med Today,1998,4:130-137.
  • 3Nagase H,Okada Y.Proteinases and matrix degradation.In:Kelley WN,Harris ED,Ruddy S,Sledge CB,eds.Textbook of rheumatology[J].Philadelphia:W.B.Saunders,1997,4:323-341.
  • 4Ahrens D,Koch AE,Pope RM,et al.Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis[J].Arthritis Rheum,1996,39:1576-1587.
  • 5Klimiuk PA,Yang H,Goronzy JJ,et al.Production of cytokines and metalloproteinases in rheumatoid arthritis is T cell dependent[J].Clin Immunol,1999,90(1):65-78.
  • 6Green MJ,Gough AKS,Devlin J,et al.Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis[J].Rheumatology (Oxford),2003,42(1):83-88.
  • 7Kane D,Gogarty M,O'leary J,et al.Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate[J].Arthritis Rheum,2004,50(10):3286-3295.
  • 8Tchetverikov I,Lard L R,De Groot J,et al.Matrix metalloproteinases-3,-8,-9 as markers of disease activity and joint damage progression in early rheumatoid arthritis[J].Ann Rheum Dis,2003,62:1094-1099.
  • 9Yoshihara Y,Nakamura H,Obata K,et al.Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis[J].Ann Rheum Dis,2000,59(6):455-461.
  • 10王慕逖 主编.儿科学:第5版[M].,2001.97.

共引文献35

同被引文献3

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部