抗感灵颗粒急性毒性的试验研究

Study on Acute Toxicity of Kang’ganling Granules

目的研究抗感灵颗粒的急性毒性反应,为临床安全用药提供依据。方法抗感灵颗粒小鼠灌胃,测定其毒性反应、死亡情况和最大耐受量。结果小鼠最大耐受量(MTD)为39.02g/kg,为临床用药的118倍。结论本制剂未发现毒性作用,其临床应用具有一定的安全性。

Objective To observe Kang’ganling granules on mice acute toxicity and provide the basis for the clinical safety of drugs.Methods Mice were intragastrically administered with Kang’ganling granules.Determine its toxicity,mortality and the maximum tolerated dose.Results The maximum tolerated dose（MTD） was 39.02 g/kg,which was 118 times than clinical dosage.Conclusion No toxicity has been found in the observation period.This preparation is relatively safe in clinical application.